College football Week 12 picks against the spread Week 12 of the college football season is here, and the three biggest games on the schedule involve matchups between ranked teams. No. 3 Notre Dame faces No. 12 Syracuse at Yankee Stadium at 2:30 p.m. in a huge matchup with College Football Playoff implications. The primetime 8 p.m. spot features matchups between No. 11 UCF and No. 19 Cincinnati and No. 13 Texas and No. 18 Iowa State.