College football Week 3 picks against the spread for every top-25 matchup Week 3 of the college football season does not have matchup between two ranked teams. Thank heavens we can bet against the spread, right? No. 19 Iowa traveling to Iowa State and No. 1 Clemson visiting Syracuse is the best we can do this week. Here is a look at our record after Week 2: Straight up: 40-6, .870 (17-5 last week) Against the spread: 27-19, .587 (10-8 last week) Upset picks: 0-2 With that in mind, here is a look at the dates, times, TV and odds (provided courtesy of Sportsbook Review as of Monday, Sept.