College football Week 6 picks against the spread for every top-25 matchup The first week of October is here, and Week 6 of the college football schedule features three matchups between ranked teams. No. 14 Iowa travels to No. 19 Michigan (noon, FOX) in a Big Ten showdown. The Wolverines will look to make up for losing to Wisconsin two weeks ago. That sets the stage for a top-10 matchup between No. 7 Auburn and No. 10 Florida (3:30 p.m., CBS). No. 25 Michigan State faces No. 4 Ohio State (7:30 p.m., ABC) in primetime.