College football Week 5 picks against the spread for every top-25 matchup Week 5 of the college football season features several large spreads. Only five games involving top-25 teams have spreads of fewer than 10 points, and the best game on the schedule might be No. 21 USC traveling to No. 17 Washington (10) in a battle of Pac-12 teams trying to avoid a College Football Playoff-eliminating loss. No. 10 Notre Dame (-11) hosts No. 18 Virginia in the only other matchup involving two ranked teams.