College football Week 6 picks against the spread for every top-25 game Week 6 of the college football season features three matchups between teams ranked in the AP Top 25, and that starts with the Red River Rivalry between No. 7 Oklahoma and No. 19 Texas at noon. No. 5 LSU travels to The Swamp to face No. 22 Florida in the 3:30 p.m. slot, and No. 6 Notre Dame travels to No. 24 Virginia Tech in primetime of what should be another fun week of picks against the spread. Here is a look at our record so far: Straight up: 90-14, .865 (17-2 last week) Against the spread: 54-36, .600 (10-9 last week) And now, Sporting News’ picks against the spread for Week 6 (lines reflect Consensus picks according to VegasInsiders.