College football Week 4 picks against the spread for every top-25 game Week 4 of the college football season is here, and we’re coming off a hot week against the spread. This week’s biggest challenges are the top 25 matchups between No. 22 Texas A&M and No. 1 Alabama and the primetime matchup between No. 7 Stanford and No. 20 Oregon. Those are the biggest pieces in the College Football Playoff heading into the week.