Indianapolis Colts vs. Houston Texans TNF Betting Preview Division rivals clash when Indianapolis visits Houston to open the NFL Week 12 schedule. NRG Stadium in Houston, TX, hosts the Thursday Night Football fight and kickoff is slated for 8:20 p.m. ET on Nov. 21, 2019. First place is on the line as the Colts and Texans are the two top AFC South contenders. Spread: Texans -4 (-110), Colts +4 (-110) Moneyline: Texans (-210), Colts (+175) Total: OVER 45.5 (-110), UNDER 45.5 (-110) Colts’ Season to Date Indianapolis (6-4) is now a tiebreaker ahead of Houston in the AFC South standings thanks to a 33-13 Week 11 win over Jacksonville.