NFL Picks Against the Spread and Expert Predictions, Tips, Parlays NFL picks and expert predictions as well as betting tips and parlays for all of this weeks games. All of our expert NFL predictions are against the spread. (ATS) This page will be updated weekly. The San Francisco 49ers take on the Kansas City Chiefs at Hard Rock Stadium (6:30 PM EST). The expected starters at QB are Jimmy Garoppolo for the 49ers and Patrick Mahomes for the Chiefs.